Research
Combined treatment with lisofylline and exendin-4 reverses autoimmune
diabetes
Biochemical and Biophysical Research Communications; Copyright 2006
Elsevier, Inc.; Published April 5, 2006;
doi:10.1016/j.bbrc.2006.03.173
A Mechanism
Linking Glucose to Inflammation - The Endocrine Society
Endocrinology published February 2, 2006 as
doi:10.1210/en.2005-0519
Activation of the 12-Lipoxygenase and Signal Transducer and Activator of
Transcription Pathway During Neointima Formation in a Model of the
Metabolic Syndrome -
Am J Physiol Endocrinol Metab (August 23, 2005).
doi:10.1152/ajpendo.00133.2005
Reversal of Type-1 Diabetes in
NOD Mice with Combination of Exendin-4 and Lisofylline - American
Diabetes Association, 65th Annual Scientific Sessions; Beta Cell
Preservation; June 2005 (PDF)
Reversal of Type-1 Diabetes in NOD Mice with Extendein-4 and
Lisofylline - The 8th Meeting of the Immunology of Diabetes
Society (October 6, 2005)
Inflammatory Blockade Improves
Human Pancreatic Islet Function and Viability - American
Journal of Transplantation 2005; 5:475-483 Blackwell Munksgaard (PDF)
Lisofylline: a potential lead for the treatment of diabetes -
Biochem
Pharmacol. 2005 Jan 1;69(1):1-5. Review.
Inflammation blockade improves pancreatic islet function -
Transplant Proc. 2004 Nov;36(9):2864-5.
Autoimmune diabetes is blocked in Stat4-deficient mice -
J Autoimmun. 2004 May;22(3):191-200.
Lisofylline, a novel anti-inflammatory agent, enhances
glucose-stimulated insulin secretion in vivo and in vitro: studies in
prediabetic and normal rats -
Metabolism.
2004 Mar;53(3):290-6.
The novel anti-inflammatory agent lisofylline prevents autoimmune
diabetic recurrence after islet transplantation -
Transplantation.
2004 Jan 15;77(1):55-60.
Inhibition of STAT4 activation by lisofylline is associated with the
protection of autoimmune diabetes -
Ann N Y Acad
Sci. 2003 Nov;1005:409-11.
Lisofylline, a Novel Antiinflammatory Compound, Protects Mesangial Cells
from Hyperglycemia- and Angiotensin II-Mediated Extracellular Matrix
Deposition - Endocrinology Vol. 144, No. 12
5227-5231
Copyright © 2003 by The Endocrine Society
The novel anti-inflammatory compound, lisofylline, prevents diabetes
in multiple low-dose streptozotocin-treated mice -
Pancreas. 2003
May;26(4):e99-104.
Lisofylline,
a Novel Antiinflammatory Agent, Protects Pancreatic ß-Cells from
Proinflammatory Cytokine Damage by Promoting Mitochondrial Metabolism
- Endocrinology Vol. 143, No. 6
2341-2348
Copyright © 2002 by The Endocrine Society
The anti-inflammatory compound lisofylline prevents Type I diabetes
in non-obese diabetic mice -
Diabetologia. 2002 Sep;45(9):1307-14.
Epub 2002 Aug 1
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